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Enhanced Oil Recovery using a Combination of Biosurfactants
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The Combination of

Jun-Woo Jang1, Dong-Woo Lim1, Ji-Ung Chang1

  • 1Department of Pathology, College of Korean Medicine, Dongguk University, Goyang 10326, Republic of Korea.

Evidence-Based Complementary and Alternative Medicine : Ecam
|September 14, 2018
PubMed
Summary
This summary is machine-generated.

Gambihwan (GBH), a Korean herbal medicine, effectively reduced body weight and improved glucose tolerance in obese mice. Both GBH types suppressed obesity markers and lipid accumulation, suggesting potential for obesity treatment.

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Area of Science:

  • Traditional Korean Medicine
  • Pharmacology
  • Obesity Research

Background:

  • Obesity is a growing global health concern with limited effective treatments.
  • Herbal prescriptions, like Gambihwan (GBH), are utilized in Korean medicine for obesity management.
  • Understanding the efficacy and mechanisms of GBH in preclinical models is crucial.

Purpose of the Study:

  • To evaluate the anti-obesity effects of two Gambihwan (GBH1 and GBH2) formulations.
  • To investigate the underlying mechanisms of GBH action in high-fat diet-induced obese mice.
  • To identify key components responsible for GBH's therapeutic effects.

Main Methods:

  • High-fat diet-induced obese mice were treated with GBH1 or GBH2 (100-200 mg/kg/day) for 8 weeks.
  • Glucose tolerance tests were performed, followed by analysis of serum insulin, lipids, and inflammatory cytokines.
  • Hepatic enzyme levels and liver lipid accumulation (Oil Red O staining) were assessed.

Main Results:

  • Both GBH1 and GBH2 significantly reduced body weight, liver weight, and adipose tissue weight.
  • GBH treatment significantly improved glucose tolerance and reduced serum/hepatic cholesterol levels.
  • GBH administration diminished inflammatory cytokines and hepatic enzymes, suppressing liver lipid accumulation.

Conclusions:

  • Gambihwan exhibits significant anti-obesity effects in a mouse model.
  • GBH improves metabolic parameters and reduces inflammation associated with obesity.
  • The combination of Ephedrae herba and Coicis semen is hypothesized to be key to GBH's anti-obesity action.