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Correlation analysis of intestinal flora with hypertension
Jilun Liu1, Ning An2, Cong Ma3
1Department of Cardiology, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang, Shaanxi 712000, P.R. China.
Experimental and Therapeutic Medicine
|September 14, 2018
Summary
Hypertension is linked to gut bacteria changes. Patients with high blood pressure had more Eubacterium rectale and less Bacteroides thetaiotaomicron and Bifidobacterium in their intestines.
Area of Science:
- Microbiology
- Cardiovascular Health
- Human Physiology
Background:
- Intestinal flora composition is increasingly recognized for its role in metabolic and cardiovascular health.
- Alterations in gut microbiota have been implicated in various diseases, including hypertension.
Purpose of the Study:
- To investigate the relationship between intestinal flora content and hypertension.
- To compare the quantities of specific gut bacteria in hypertensive patients and healthy individuals.
Main Methods:
- A case-control study involving 94 hypertensive patients and 94 healthy controls.
- Measurement of systolic blood pressure (SBP) and diastolic blood pressure (DBP).
- Quantification of Eubacterium rectale, Bacteroides thetaiotaomicron, and Bifidobacterium using reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
- Correlation analysis between bacterial quantities and blood pressure levels.
Main Results:
- Hypertensive patients exhibited significantly higher SBP, DBP, and Eubacterium rectale levels compared to controls.
- Conversely, hypertensive patients showed significantly lower levels of Bacteroides thetaiotaomicron and Bifidobacterium.
- Eubacterium rectale showed a positive correlation with SBP and DBP, while Bacteroides thetaiotaomicron and Bifidobacterium displayed a negative correlation.
Conclusions:
- Hypertension is associated with a decrease in Bifidobacterium and Bacteroides thetaiotaomicron and an increase in Eubacterium rectale.
- Intestinal flora composition significantly correlates with hypertension, suggesting a potential role in its pathogenesis.
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