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Effect of montelukast on the expression of CD4
Xiaoting Qu1, Yuan Chen2, Chaoyang Yin1
1Department of Pediatrics, Shangluo Central Hospital, Shangluo, Shaanxi 726000, P.R. China.
Insights
Montelukast treatment significantly improved asthma symptoms and lung function in children. It also increased regulatory T cells and modulated inflammatory markers, suggesting a beneficial effect on airway inflammation.
Area of Science:
- Immunology
- Pediatric Pulmonology
- Pharmacology
Background:
- Acute bronchial asthma in children presents significant clinical challenges.
- Understanding the role of regulatory T cells in asthma pathogenesis is crucial for developing effective therapies.
Purpose of the Study:
- To investigate the impact of montelukast on CD4+CD25+ regulatory T cells in pediatric acute bronchial asthma.
- To evaluate montelukast's effects on clinical symptoms, lung function, and inflammatory markers in asthmatic children.
Main Methods:
- A randomized controlled trial involving 56 children with acute bronchial asthma.
- Comparison between conventional therapy and montelukast combined with conventional therapy for 7 days.
- Assessment of clinical symptoms, lung function (FEV1/FVC, PEF, PEF25), CD4+CD25+ T cells, inflammatory cytokines (IL-4, IL-5, IL-6, TFN-γ, IL-10), and immunoglobulin E (IgE).
Main Results:
- Montelukast significantly improved treatment efficacy, clinical symptoms, and lung function parameters compared to conventional therapy.
- Treatment with montelukast led to a significant increase in CD4+CD25+ regulatory T cells.
- Montelukast modulated inflammatory profiles by decreasing IL-4, IL-5, and IL-6, while increasing TFN-γ and IL-10, and significantly affected IgE levels.
Conclusions:
- Montelukast effectively improves acute bronchial asthma in children by enhancing regulatory T cell expression.
- The drug helps rebalance T helper 1 (Th1)/Th2 immune responses, reducing airway inflammation.
- Montelukast demonstrates significant clinical benefits, improving symptoms and lung function in pediatric asthma patients.
Abstract:
The aim of this study was to investigate the effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Fifty-six child patients with acute bronchial asthma treated in the Department of Pneumology at the Shangluo Central Hospital were selected and randomly divided into the control group (n=28) and treatment group (n=28). The control group was treated with the conventional therapy of bronchial asthma, while the treatment group received montelukast on the basis of the control group for 7 days. The clinical symptoms, lung function and proportion of CD4+CD25+ regulatory T cells in peripheral T lymphocyte subsets in patients in the two groups were observed. Moreover, the levels of inflammatory factors and immunoglobulin E (IgE) in peripheral blood in both groups were detected. The effective treatment rate in the treatment group was significantly higher than that in the control group (P<0.05), and the forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF) and 25% peak expiratory flow (PEF25) in the treatment group were significantly higher than those in the control group (P<0.05). The proportions of CD4+CD25+ regulatory T cells in the two groups after drug therapy were significantly increased. The proportion and content per unit volume of peripheral CD4+CD25+ regulatory T cells in the treatment group were obviously higher than those in the control group (P<0.01). After treatment, the levels of interleukin-4 (IL-4), IL-5 and IL-6 in peripheral blood in the two groups were significantly decreased. However, the levels of transferrin-γ (TFN-γ) and IL-10 were significantly increased (P<0.01). The IgE level in the treatment group was also significantly higher than that in the control group (P<0.01). In conclusion, montelukast can regulate the T helper 1 (Th1)/Th2 balance, increase the expression of CD4+CD25+ regulatory T cells, and improve the airway inflammation caused by acute bronchial asthma and the clinical symptoms and lung function of patients with acute bronchial asthma.
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