Related Experiment Video

Updated: Feb 5, 2026

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
07:53

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

7.7K

Loss of UHRF2 Is Associated With Non-small Cell Lung Carcinoma Progression

Chun Jin1, Dian Xiong2, Hao-Ran Li1

  • 1Department of Thoracic Surgery, The Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, P. R. China.

Journal of Cancer
|September 14, 2018
PubMed

Insights

Ubiquitin like with PHD and ring finger domains 2 (UHRF2) acts as a tumor suppressor in non-small cell lung cancer (NSCLC). Decreased UHRF2 expression promotes cancer progression and is linked to poorer patient survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ubiquitin like with PHD and ring finger domains 2 (UHRF2) has been implicated in human diseases, but its specific role in cancer remains unclear.
  • Existing research presents conflicting evidence regarding the function of UHRF2 in oncogenesis.

Purpose of the Study:

  • To investigate the role of UHRF2 in non-small cell lung cancer (NSCLC).
  • To explore the molecular mechanisms underlying UHRF2's function in NSCLC.
  • To evaluate the clinical significance of UHRF2 expression in NSCLC patients.

Main Methods:

  • Analysis of UHRF2 expression in lung cancer tissues using the Oncomine Database.
  • Experimental validation of UHRF2 expression via immunoblotting and quantitative real-time polymerase chain reaction (qRT-PCR).
  • In vitro studies involving UHRF2 knockdown and overexpression in NSCLC cell lines (A549, 95-D).
  • Assays to assess the correlation between UHRF2, ten-eleven translocation 2 (TET2) expression, and 5-hydroxymethylcytosine (5-hmC) levels.

Main Results:

  • UHRF2 expression was significantly decreased in lung cancer tissues compared to normal tissues.
  • Knockdown of UHRF2 promoted proliferation, invasion, and migration of NSCLC cells, while its overexpression inhibited these processes.
  • UHRF2 expression positively correlated with TET2 expression and 5-hmC levels.
  • Downregulation of UHRF2 was associated with advanced tumor characteristics (larger size, poor differentiation) and shorter overall survival in NSCLC patients.

Conclusions:

  • UHRF2 functions as a tumor suppressor in NSCLC.
  • UHRF2 exerts its tumor-suppressive effects possibly through the regulation of TET2 expression, impacting 5-hmC levels.
  • UHRF2 represents a potential therapeutic target for NSCLC treatment.
Keywords:
5-hmCNSCLCUHRF2demethylation

More Related Videos

Detection of Lung Tumor Progression in Mice by Ultrasound Imaging04:43

Detection of Lung Tumor Progression in Mice by Ultrasound Imaging

Published on: February 27, 2020

7.4K
Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs05:11

Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs

Published on: May 10, 2024

1.9K

Related Concept Videos

Line Loss01:10

Line Loss

The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
545
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
390
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Energy Losses in Transformers01:21

Energy Losses in Transformers

In an ideal transformer, it is assumed that there are no energy losses, and, hence, all the power at the primary winding is transferred to the secondary winding. However, in reality,  the transformers always have some energy losses, and, hence, the output power obtained at the secondary winding is less than the input power at the primary winding due to energy losses.
There are four main reasons for energy losses in transformers.
The first cause can be  the high resistance of the...
1.3K
Major Losses in Pipes01:28

Major Losses in Pipes

When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
2.0K