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Association between circulating fibrocytes and angiographic coronary collaterals in patients with obstructive

Mary C Shields1, Borna Mehrad2,3, Ellen C Keeley2,4

  • 1Department of Medicine, Division of Cardiology, University of Virginia Charlottesville, Virginia.

American Journal of Translational Research
|September 14, 2018
PubMed

Insights

Elevated circulating fibrocytes, a type of bone marrow-derived cell, are linked to the presence of coronary artery collaterals in patients with stable coronary artery disease. This suggests fibrocytes may play a role in collateral vessel formation.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Regenerative Medicine

Background:

  • Circulating fibrocytes are bone marrow-derived progenitor cells involved in neovascularization.
  • Coronary artery collateral recruitment improves outcomes in coronary artery disease.
  • The role of fibrocytes in collateral formation is not fully understood.

Purpose of the Study:

  • To investigate the association between circulating fibrocyte concentration and the presence of angiographic coronary collaterals in patients with stable chronic coronary artery disease.

Main Methods:

  • Fifty-eight subjects with significant coronary artery stenosis were enrolled.
  • Coronary angiography was used to assess the presence of collateral vessels.
  • Blood concentrations of activated fibrocytes were measured.

Main Results:

  • Forty-five percent of subjects (26 out of 58) exhibited angiographic coronary collaterals.
  • Subjects with coronary collaterals showed significantly higher circulating concentrations of activated fibrocytes.
  • A positive association was observed between fibrocytes and coronary collateral recruitment.

Conclusions:

  • Circulating activated fibrocytes are associated with the presence of coronary collaterals in patients with stable coronary artery disease.
  • These findings suggest a potential role for fibrocytes in the development of coronary collateral vessels.
  • Further research is warranted to elucidate the precise mechanisms.

Keywords:
Coronary collateralscirculating fibrocytes

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