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Relationship between CD44

Ana Livia Silva Galbiatti-Dias1, Glaucia Maria Mendonça Fernandes1, Marcia Maria Urbanin Castanhole-Nunes1

  • 1Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP) SP, Brazil.

American Journal of Cancer Research
|September 14, 2018
PubMed
Summary

Cancer stem cells (CSCs) exhibit resistance to Paclitaxel chemotherapy in oral cancer cell lines. These CSCs show distinct CD44 and EGFR gene expression patterns, impacting treatment outcomes.

Keywords:
CD44Cancer stem cellsEGFRcell linechemotherapyexpressiongenehead and neck neoplasias

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Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Medicine

Background:

  • Cancer stem cells (CSCs) are implicated in tumor recurrence, metastasis, and therapeutic resistance.
  • Identifying and characterizing CSCs is crucial for developing effective cancer treatments.
  • Head and neck cancers present unique challenges due to their complex biology and treatment resistance.

Purpose of the Study:

  • To identify and characterize CD44high/CD133high/CD117high (CSCs) and CD44low/CD133low/CD117low (Non-CSCs) populations in head and neck cancer cell lines.
  • To investigate the influence of chemotherapy (Cetuximab, Paclitaxel) on CSCs and Non-CSCs.
  • To evaluate CD44 and EGFR gene expression in CSCs and Non-CSCs.

Main Methods:

  • Fluorescent-activated cell sorting (FACS) using CD44, CD117, and CD133 markers to isolate CSCs and Non-CSCs.
  • Wound Healing assay to confirm CSC presence.
  • Cell proliferation assays (MTS) and quantitative real-time PCR (qPCR) to assess treatment response and gene expression (CD44, EGFR).

Main Results:

  • CSCs were successfully identified and characterized in HN13 and HEP-2 cell lines using CD44, CD133, and CD117 biomarkers.
  • CSCs demonstrated increased resistance to Paclitaxel chemotherapy compared to Non-CSCs in the oral cancer cell line.
  • Differential gene expression of CD44 and EGFR was observed in CSCs between oral and laryngeal cancer cell lines.

Conclusions:

  • The combination of CD44, CD133, and CD117 markers effectively identifies CSCs with stem cell properties in head and neck cancer cell lines.
  • CSCs exhibit resistance to Paclitaxel in oral cancer, highlighting their role in therapeutic failure.
  • Distinct CD44 and EGFR gene expression profiles in CSCs from different head and neck cancer subtypes warrant further investigation for targeted therapies.