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Penile transplantation: the US experience and institutional program set-up.
April Adams Szafran1, Richard Redett1, Arthur L Burnett1
1Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Translational Andrology and Urology
|September 14, 2018
Summary
Penile transplantation using vascularized composite allografts offers a new solution for genital loss. Rigorous candidate selection and optimized protocols are crucial for successful outcomes and managing immunosuppression.
Area of Science:
- Urology
- Transplant Surgery
- Regenerative Medicine
Background:
- Genital loss presents significant challenges for quality of life.
- Vascularized composite allografts (VCAs) are an emerging option for reconstructive surgery.
- Penile transplantation is a complex procedure with potential applications for specific patient populations.
Purpose of the Study:
- To review the emerging technique of penile transplantation.
- To outline the candidate selection process for genitourinary (GU) VCA surgery.
- To discuss critical considerations for post-transplant management.
Main Methods:
- Review of current practices and research protocols for penile transplantation.
- Description of the multi-faceted candidate screening process.
- Discussion of immunosuppression management strategies.
Main Results:
- Successful penile transplantation has been performed in the US for cancer survivors.
- Research protocols are established for trauma-related genital loss.
- Careful patient selection and immunosuppression management are key.
Conclusions:
- Penile transplantation is a viable surgical option for select patients with genital loss.
- Optimization of pre-operative screening, surgical technique, and immunosuppression is necessary.
- Further research is required to establish penile transplant as a standard treatment.
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