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Absorption of

Yaping Jing1,2,3, Anping Li4, Zhirong Liu4

  • 1School of Life Sciences, Lanzhou University, Lanzhou 730000, China.

Biomed Research International
|September 14, 2018
PubMed
Summary
This summary is machine-generated.

Codonopsis pilosula Nannf (CPN) polysaccharides exhibit prebiotic effects, promoting beneficial gut bacteria and inhibiting harmful ones in inflammatory bowel disease (IBD) models. This research highlights their therapeutic potential for acute colitis.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Immunology

Background:

  • Inflammatory Bowel Disease (IBD) is an autoimmune condition where gut microbiota modulation is a key therapeutic strategy.
  • Herbal medicine (HM) shows efficacy in IBD, but the synergistic effects of its active compounds remain unclear.
  • Codonopsis pilosula Nannf (CPN) is a significant herb, with saponins and polysaccharides as its dominant chemical constituents.

Purpose of the Study:

  • To investigate the prebiotic-like effects of CPN polysaccharides on gut microbiota composition and function in a dextran sulfate sodium- (DSS-) induced colitis mouse model.
  • To elucidate the impact of CPN polysaccharides on the gut microbiota, intestinal metabolism, immune response, and absorption of CPN saponins.
  • To explore the potential of CPN polysaccharides in the prevention and treatment of acute colitis.

Main Methods:

  • Induction of colitis in mice using DSS and administration of CPN decoction.
  • Analysis of gut microbiota structure and diversity using 16S rRNA sequencing.
  • Quantification of short-chain fatty acids (SCFAs) via gas chromatography (GC).
  • Detection of cytokine expression (pro- and anti-inflammatory) using ELISA.
  • Assessment of CPN saponin absorption using UPLC-QTOF-MS and PKsolver software.

Main Results:

  • CPN polysaccharides demonstrated prebiotic effects by promoting probiotics (Bifidobacterium, Lactobacillus, Akkermansia) and inhibiting pathogens (Desulfovibrio, Alistipes, Helicobacter).
  • Significant improvements were observed in intestinal metabolism and SCFA production.
  • Upregulation of anti-inflammatory cytokines and downregulation of pro-inflammatory cytokines were noted, indicating a shift in Th17/Treg balance.
  • Enhanced absorption of certain CPN saponins was observed, alongside the recovery of overall gut microbiota structure.

Conclusions:

  • CPN polysaccharides possess significant prebiotic properties, making them promising for preventing and treating acute colitis.
  • These findings provide valuable insights into the specific bacterial interactions involved in the biotransformation and effects of herbal medicine ingredients.
  • The study underscores the potential of CPN polysaccharides in restoring gut microbiota homeostasis and mitigating inflammatory responses in IBD.