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Role of the CHADS

Le-Yu Lin1,2, Lian-Wei Yang1,3, Yuan-Yuan Shang1

  • 1The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health and the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Biomed Research International
|September 14, 2018
PubMed

Insights

Patients with atrial fibrillation (AF) show altered carotid artery structure and function. The CHADS2 score may help predict the severity of carotid atherosclerosis in these patients.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Medical Imaging

Background:

  • Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of stroke.
  • Carotid atherosclerosis is a significant risk factor for cerebrovascular events.

Purpose of the Study:

  • To investigate carotid atherosclerosis characteristics in patients with atrial fibrillation (AF).
  • To assess the feasibility and predictive value of the CHADS2 score for carotid atherosclerosis severity in AF patients.

Main Methods:

  • 109 patients with nonvalvular AF (paroxysmal and persistent) and 50 healthy controls underwent carotid ultrasound and velocity vector imaging (VVI).
  • Patients were categorized into paroxysmal AF, persistent AF, and control groups.

Main Results:

  • Significantly increased intimal-medial thickness and plaque index were observed in both AF groups compared to controls.
  • Velocity vector imaging (VVI) revealed decreased carotid artery longitudinal motion function in AF patients.
  • The CHADS2 score demonstrated a correlation with carotid artery structure and function indicators.

Conclusions:

  • Carotid artery structure and function are significantly altered in patients with AF.
  • The extent of carotid atherosclerosis is influenced by AF duration.
  • The CHADS2 score shows potential as a predictor for carotid atherosclerosis extent in AF patients.
Abstract

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