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The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma

Xueyun Zhao1,2, Mingqiang Hua1, Shuxin Yan1

  • 1Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Journal of Immunology Research
|September 14, 2018
PubMed

Insights

Genetic variations in NLRP3 inflammasome genes like CARD8 and NF-κB are linked to multiple myeloma (MM) susceptibility and progression. These genetic factors also correlate with T helper cell responses in MM patients.

Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • The pathogenesis of multiple myeloma (MM) is not fully understood.
  • The NLRP3 inflammasome is increasingly implicated in disease progression.

Purpose of the Study:

  • To investigate the role of NLRP3 inflammasome genetic polymorphisms and gene expression in MM.
  • To explore the clinical relevance of these genetic factors.
  • To examine the relationship between the NLRP3 inflammasome and T helper (Th) cells in MM.

Main Methods:

  • Genotyping of NLRP3 inflammasome-related genes (IL-1β, IL-18, CARD8, NF-κB) in MM patients.
  • Analysis of gene expression and correlation with clinical parameters.
  • Investigation of the association with Th cell populations.

Main Results:

  • The CARD8-C10X (rs2043211) AT genotype was associated with MM susceptibility.
  • CARD8-C10X TT genotype correlated with earlier clinical stages.
  • Specific genotypes of CARD8 and NF-κB-94 ins/del were linked to Th1 cell frequency.
  • IL-18 (rs16944) TT genotype was associated with higher hemoglobin levels.

Conclusions:

  • Genetic polymorphisms in NLRP3 inflammasome-associated genes, particularly CARD8 and NF-κB, may contribute to MM pathogenesis.
  • These genetic variations are linked to clinical features and Th cell responses in MM.
  • NLRP3 inflammasome genetic factors and Th cells are potentially involved in the development of multiple myeloma.

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