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Data on nephroprotective effect of all-trans retinoic acid in early diabetic nephropathy

Edith Sierra-Mondragón1, Eduardo Molina-Jijón2, Carmen Namorado-Tónix1

  • 1Departamento de Fisiología, Biofísica, y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México CDMX 07360, Mexico.

Data in Brief
|September 14, 2018
PubMed

Insights

All-trans retinoic acid (ATRA) can reduce inflammation and kidney damage in early diabetic nephropathy. This vitamin A metabolite helps protect against glomerular and tubular dysfunction in diabetic rats.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic nephropathy (DN) is a leading cause of kidney failure.
  • Inflammation, involving cytokines and chemokines, significantly contributes to DN-induced renal injury.
  • Understanding early-stage DN mechanisms is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the therapeutic effect of all-trans retinoic acid (ATRA) on renal alterations in early DN.
  • To determine ATRA's impact on inflammation mediated by TLR4/NF-κB signaling in DN.
  • To assess ATRA's protective effects on glomerular and tubular function in diabetic kidneys.

Main Methods:

  • Utilized physical-biochemical measurements and Western blot assays.
  • Analyzed isolated glomeruli, proximal tubules, and distal tubules from rat kidneys.
  • Focused on an initial stage of diabetic nephropathy.

Main Results:

  • ATRA demonstrated a protective effect against renal alterations in early DN.
  • ATRA ameliorated inflammatory responses, specifically those mediated by TLR4/NF-κB.
  • The treatment improved both glomerular and tubular function in diabetic rat kidneys.

Conclusions:

  • All-trans retinoic acid shows potential as a therapeutic agent for early diabetic nephropathy.
  • ATRA effectively reduces inflammation and preserves kidney function in the context of diabetes.
  • Targeting TLR4/NF-κB pathways with ATRA may be a viable strategy for managing DN.
Keywords:
All-trans retinoic acidCytokinesDiabetic nephropathyInflammation

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