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Bilateral Hip Fracture in Adolescents With Antiretroviral Treatment
Poblete Marco1, Artigas Cristian1, Galaz Maria Isabel1
1Service Pediatric Orthopaedic Surgery, Roberto del Rio Children´s Hospital, Santiago, Chile.
Abstract:
Tenofovir is a nucleotide reverse transcriptase inhibitor, a commonly prescribed antiretroviral as part of initial therapy. It is widely used and has been recognized as a cause of acquired Fanconi syndrome, a disorder characterized by renal tubular dysfunction, which leads to hypophosphatemia, hypokalemia, and metabolic acidosis, as well as symptoms of polyuria and dehydration, which can ultimately lead to defects in bone mineralization and increase risk of fracture.
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