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Updated: Aug 18, 2026
12:28
Preparation of Highly Coupled Rat Heart Mitochondria
Published on: September 24, 2010
Mechanism of adenosine production by isolated rat heart mitochondria
Biochimica Et Biophysica Acta
|October 29, 1986
Abstract:
Adenosine production by isolated rat heart mitochondria was examined and was observed to be dependent on an active adenine nucleotide transporter and a functional 5'-nucleotidase. It was found that mitochondria do not transport adenosine. These results suggest that mitochondria provide AMP for an extramitochondrial 5'-nucleotidase and this was verified by direct measurement of extramitochondrial levels of AMP and adenosine. A possible role for mitochondria in myocardial adenosine production is discussed.
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