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Updated: Feb 5, 2026

Ganglioside Extraction, Purification and Profiling
Published on: March 12, 2021
A geometric morphometric evaluation of hard and soft tissue profile changes in borderline extraction versus
Afroditi Kouli1, Alexandros Papagiannis1, Nikoleta Konstantoni2
1Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Objectives:
To evaluate the hard tissue and facial profile changes in matched extraction and non-extraction Class I patients by the use of geometric morphometrics.
Subjects And Methods:
From a parent sample of 542 Class I patients, previously subjected to discriminant analysis, a subsample of 68 borderline cases was obtained, 34 treated with extraction and 34 without extraction of 4 first premolars. Geometric morphometric methods (Procrustes superimposition and Principal Component Analysis) were applied on cephalometric tracings to assess the validity of the discriminant analysis in successfully identifying a morphologically homogeneous group and to evaluate inter- and intra-group skeletal and facial profile shape changes.
Results:
No significant pre-treatment shape difference between the two groups was found, thus validating the discriminant analysis. The non-extraction group showed increase in hard tissue facial height (P < 0.001), with slight lower lip retrusion and upper lip protrusion (P = 0.027). The extraction group showed retraction of the hard tissue and facial profile outline (P < 0.001). Permutation tests for post-treatment inter-group differences resulted in P = 0.054 for the soft tissue outline and P = 0.078 for the hard tissue skeletal component.
Conclusions:
The evidence indicates that borderline cases treated with four premolar extractions will exhibit lip retrusion compared to non-extraction treatment.
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