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Hemagglutination ability and hemolytic activity of Trichosporon asahii

Tomoe Ichikawa1, Kota Uchiyama1, Yuta Yoshizawa1

  • 1Department of Microbial Science and Host Defense, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.

Medical Mycology
|September 14, 2018
PubMed

Insights

Trichosporon asahii exhibits hemolytic and hemagglutination activities. Cell surface molecules are involved in the hemagglutination of adherent strains, suggesting these activities may contribute to fungal pathogenicity.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pathogen Biology

Background:

  • Trichosporon asahii is a human fungal pathogen causing deep-seated infections.
  • Previous studies suggest adherent colony morphologies may contribute to T. asahii pathogenicity.
  • The precise pathogenic mechanisms of T. asahii are not fully understood.

Purpose of the Study:

  • To investigate the hemolytic and hemagglutination activities of Trichosporon asahii.
  • To explore the role of cell surface molecules in the hemagglutination activity of adherent T. asahii strains.

Main Methods:

  • Analysis of hemolytic activity in T. asahii.
  • Assessment of hemagglutination activity in T. asahii.
  • Investigation of cell surface molecule involvement in hemagglutination.

Main Results:

  • Trichosporon asahii cells demonstrated significant hemolytic activity.
  • T. asahii cells exhibited hemagglutination activity.
  • Cell surface molecules were identified as playing a role in the hemagglutination activity of adherent strains.

Conclusions:

  • Hemolytic and hemagglutination activities are characteristic of T. asahii.
  • These activities, particularly hemagglutination involving cell surface molecules, may represent key pathogenic mechanisms of T. asahii.
  • Further research into these mechanisms can inform strategies for treating T. asahii infections.
Keywords:
Trichosporon asahiicolony morphologyhemaggulutinationhemolytic activitypathogenic characteristics

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