New Antibacterial Bagremycins F and G from the Marine-Derived
Di Zhang1, Chenyan Shu2, Xiaoyuan Lian3
1Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China. zhangdi163.love@163.com.
Abstract:
As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively.
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