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Chemical Constituents from

Wen-Hui Xu1, Wei-Yi Liu2, Qian Liang3

  • 1Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, China. wenhuix001@hotmail.com.

Molecules (Basel, Switzerland)
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

This review highlights new chemical compounds from Croton species, focusing on diterpenoids. These compounds show diverse biological activities, suggesting potential medicinal applications for Croton plants.

Keywords:
Croton speciesbiological activitiescytotoxicityditerpenoidsphytochemistry

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • The genus Croton (Euphorbiaceae family) comprises about 1300 species, many with traditional medicinal uses.
  • This review covers chemical constituents and biological activities of Croton species from 2006 to 2018.

Purpose of the Study:

  • To review novel chemical constituents isolated from Croton species.
  • To summarize the biological activities of these constituents.
  • To identify potential leads for drug discovery from Croton species.

Main Methods:

  • Literature search for studies published between 2006 and 2018.
  • Identification and characterization of chemical compounds from Croton species.
  • Evaluation of biological activities of isolated compounds.

Main Results:

  • 399 new compounds were reported, with 339 being diterpenoids.
  • Diterpenoids are characteristic chemical components of Croton species.
  • Isolated compounds demonstrated broad bioactivities, including cytotoxic, anti-inflammatory, antifungal, acetylcholinesterase inhibitory, and neurite outgrowth-promoting effects.

Conclusions:

  • Croton species are rich sources of diverse chemical compounds, particularly diterpenoids.
  • These compounds possess significant biological activities, indicating therapeutic potential.
  • Further research into Croton chemical constituents could lead to the development of new medicines.