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Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
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Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

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[Bone and metabolism].

Charlotte Marsot1, Philippe Chanson2, Françoise Borson-Chazot1

  • 1Fédération d'endocrinologie, diabétologie et maladies métaboliques, hôpital Louis-Pradel, 59, boulevard Pinel, 69500 Bron, France.

Annales D'Endocrinologie
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Bone functions as an endocrine organ, regulating phosphate, glucose, and energy metabolism through hormones like fibroblast growth factor 23 and osteocalcin. Understanding bone

Keywords:
BoneDiabetesDiabèteEnergy metabolismMétabolisme énergétiqueOs

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Area of Science:

  • Endocrinology
  • Metabolic Bone Disease
  • Diabetes Research

Background:

  • Bone is increasingly recognized as an endocrine organ.
  • Its endocrine roles in phosphate, glucose, and energy metabolism are under investigation.
  • Diabetes negatively impacts bone health, increasing fracture risk.

Purpose of the Study:

  • To explore the endocrine functions of bone.
  • To review the relationship between diabetes and bone fragility.
  • To highlight potential therapeutic targets for diabetes and obesity.

Main Methods:

  • Review of recent findings on bone's endocrine functions.
  • Analysis of the impact of diabetes on bone metabolism.
  • Discussion of novel hormones and their mechanisms.

Main Results:

  • Bone regulates phosphate via fibroblast growth factor 23.
  • Bone influences glucose metabolism through osteocalcin.
  • Lipocalin 2, a novel hormone, impacts energy metabolism.
  • Diabetes is associated with decreased bone turnover and demineralization.

Conclusions:

  • Bone's endocrine functions are crucial for systemic metabolism.
  • Diabetes-induced bone fragility mechanisms require further elucidation.
  • Targeting bone's metabolic roles may offer new therapeutic strategies for metabolic diseases.