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Feline Injection Site Sarcomas: Data from Switzerland 2009-2014.

R Graf1, F Guscetti2, M Welle3

  • 1Collegium Helveticum, Universität Zürich und Eidgenössische Technische Hochschule Zürich, Switzerland.

Journal of Comparative Pathology
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Feline injection site sarcomas (FISS) incidence decreased after a non-adjuvanted vaccine debut. This suggests alum-adjuvanted vaccines may contribute to FISS development, indicating non-adjuvanted options could be safer for cats.

Keywords:
catfeline leukaemia virusfibrosarcomavaccine

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Area of Science:

  • Veterinary Oncology
  • Immunology
  • Pathology

Background:

  • Feline injection site sarcomas (FISS) are tumors linked to vaccine injections.
  • The exact cause of FISS remains unclear, but chronic inflammation is suspected.
  • The role of alum adjuvants in vaccine-induced tumors is debated.

Purpose of the Study:

  • To analyze trends in FISS incidence in Switzerland.
  • To investigate the potential link between vaccine types and FISS development.
  • To assess the impact of introducing non-adjuvanted vaccines on FISS rates.

Main Methods:

  • Analysis of data from the Swiss Feline Cancer Registry (SFCR) between 2009 and 2014.
  • Comparison of fibrosarcoma incidence rates before and after 2007.
  • Correlation of FISS incidence with vaccine types used in Switzerland.

Main Results:

  • A significant decrease in fibrosarcoma incidence was observed from 2009 to 2014.
  • This decline coincided with the introduction of a non-adjuvanted feline leukemia virus vaccine in 2007.
  • Previous SFCR findings support the association between alum-adjuvanted vaccines and FISS.

Conclusions:

  • The study provides further evidence implicating alum-adjuvanted vaccines in FISS genesis.
  • Non-adjuvanted vaccines may represent a safer alternative for feline vaccination.
  • Continued research into FISS pathogenesis and prevention strategies is warranted.