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Implantation of Tissue-Engineered Vascular Graft in Mouse Carotid Artery via Cuff Technique
Published on: May 2, 2025
Development of HLA-matched vascular grafts utilizing decellularized human umbilical artery
Panagiotis Mallis1, Efstathios Michalopoulos2, Amalia Dinou2
1Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece; Department of Biological Chemistry, Medical School, National and Kapodistrian Univesity of Athens, Greece.
Abstract:
Worldwide, there is a great need of small diameter vascular grafts that can be used in human disorders such as cardiovascular and peripheral vascular disease. Until now, severe adverse reactions are caused from the use of synthetic or animal derived grafts, while the use of autologous vessels is restricted only in a small number of patients. The limited availability of the vessels might be resolved by the use of HLA-matched vascular grafts utilizing the decellularized human umbilical arteries. In this study, human umbilical arteries were decellularized and then repopulated with Mesenchymal Stem Cells. The HLA-genotype of the repopulated grafts, analyzed by Next Generation Sequencing technology, indicated their successful production. The HLA-matched vascular grafts could be generated efficiently and might be used in personalized medicine.
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