Related Experiment Video
Updated: Feb 5, 2026

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
Published on: October 27, 2020
Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural
Mst Ara Gulshan1, Kasumi Tsuji2, Shigeyoshi Matsumura1
1Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, Gofuku 3190, Toyama, 930-8555, Japan; Graduate School of Innovative Life Science, University of Toyama, Gofuku 3190, Toyama, 930-8555, Japan.
Abstract:
Among cationic molecules that can modulate ribozyme activities, polyamines act as both activator and inhibitor of ribozyme reactions partly due to their structural flexibility. Restriction of structural flexibility of polyamines may allow them to emphasize particular modulation effects. We examined eight stereoisomers of a synthetic pentamine bearing three cyclopentane rings. In the reaction of a structurally unstable group I ribozyme, three stereoisomers exhibited distinct effects as inhibitor, an additive with a neutral effect, and also as an activator.
Related Concept Videos
Ribozymes
Ribozymes can...
Ribozymes
Stereoisomers
Constraints and Statical Determinacy
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...

