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Related Concept Videos

Vector Algebra: Graphical Method01:10

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In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
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Related Experiment Video

Updated: Feb 5, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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New Methods for Disease Modeling Using Lentiviral Vectors.

Arantzazu Alfranca1, Miguel R Campanero2, Juan Miguel Redondo3

  • 1Department of Immunology, Hospital Universitario de La Princesa, Madrid, Spain; CIBERCV, Madrid, Spain.

Trends in Molecular Medicine
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Lentiviral vectors (LVs) offer a safe and effective gene therapy tool for studying aortic diseases. This research demonstrates their utility in modeling aortic aneurysm formation and identifying potential therapeutic targets.

Keywords:
aortic aneurysmdisease modelsgene therapylentiviral vectorsviral targeting

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Area of Science:

  • * Molecular and Cellular Biology
  • * Gene Therapy
  • * Cardiovascular Research

Background:

  • * Lentiviral vectors (LVs) are crucial for stable transgene expression in quiescent cells.
  • * Optimizing LV safety and targeting is essential for effective gene therapy.
  • * Current methods for studying aortic diseases often rely on genetically modified mice.

Purpose of the Study:

  • * To develop and validate lentiviral vector (LV) models for studying aortic diseases.
  • * To investigate pathways involved in aortic aneurysm formation using LVs.
  • * To identify potential gene therapy targets for aortic diseases.

Main Methods:

  • * Development of pleiotropic lentiviral vectors (LVs) for efficient transduction.
  • * Administration of LVs via a single injection in wild-type mice.
  • * Analysis of LV transduction across all three layers of the aorta.

Main Results:

  • * LV models successfully transduced all three layers of the aorta in wild-type mice.
  • * This approach facilitated the dissection of pathways in aortic aneurysm formation.
  • * LVs proved to be a rapid, efficient, and cost-effective alternative to traditional genetically modified mouse models.

Conclusions:

  • * Lentiviral vectors (LVs) provide a powerful tool for modeling aortic diseases.
  • * LV-based models accelerate the study of disease mechanisms and therapeutic target identification.
  • * LVs offer a practical and affordable alternative for cardiovascular research and gene therapy development.