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Autotherapies: Enhancing Endogenous Healing and Regeneration.

Nadya Lumelsky1, Morgan O'Hayre1, Preethi Chander1

  • 1National Institute of Dental and Craniofacial Research, National Institutes of Health, 6701 Democracy Blvd., Bethesda, MD 20892-4878, USA.

Trends in Molecular Medicine
|September 15, 2018
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Summary

This study introduces autotherapies, a novel in vivo regenerative medicine approach. By optimizing the body's natural healing and stem cell environments, autotherapies enhance tissue regeneration for improved disease treatment.

Keywords:
autotherapiesendogenous tissue regenerationinflammation resolutionlineage reprogrammingproregenerative tissue microenvironmentstem cell niche

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Developmental Biology
  • Immunology
  • Bioengineering
  • Material Sciences

Background:

  • Tissue engineering and regenerative medicine aim to reduce disease burden and improve quality of life.
  • Current approaches involve in vitro tissue construct generation or exogenous cell transplantation, with limited clinical success.
  • Advances in related scientific fields enable a new generation of therapies.

Purpose of the Study:

  • To propose a new paradigm for regenerative medicine therapies termed autotherapies.
  • To leverage recent scientific advances for in vivo regenerative strategies.
  • To enhance endogenous tissue healing and regeneration.

Main Methods:

  • Developing strategies based on optimizing endogenous tissue responses.
  • Capitalizing on manipulation of stem cell niches.
  • Utilizing endogenous tissue microenvironments for enhanced healing.

Main Results:

  • Autotherapies represent a shift from traditional in vitro methods.
  • These strategies enhance the body's innate regenerative capabilities.
  • Successful implementation could lead to more effective regenerative therapies.

Conclusions:

  • Autotherapies offer a promising new direction for regenerative medicine.
  • This in vivo approach capitalizes on endogenous biological processes.
  • Further development holds potential for significant clinical impact.