Related Experiment Video
Updated: Feb 5, 2026

Computer-Generated Animal Model Stimuli
Published on: July 29, 2007
A new method for discovering EMAST sequences in animal models of cancer
Nitya Bhaskaran1, Jennifer Luu1, Scott T Kelley1
1Department of Biology, Molecular Biology Institute, San Diego State University, San Diego, CA, 92182, USA.
Abstract:
Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) occur in up to 60% of colorectal cancers and may associate with aggressive and advanced disease in patients. Although EMAST occurs in many cancer types, current understanding is limited due to the lack of an animal model. Reported here is the design and implementation of an algorithm for detecting EMAST repeats in mice. This algorithm incorporates properties of known human EMAST sequences to identify repeat sequences in animal genomes and was able to identify EMAST-like sequences in the mouse. Seven of the identified repeats were analyzed further in a colon cancer mouse model and six of the seven displayed EMAST instability characteristic of that seen in human colorectal cancers. In conclusion, the algorithm developed successfully identified EMAST repeats in an animal genome and, for the first time, EMAST has been shown to occur in a mouse model of colon cancer.
Related Concept Videos
Per-Unit Sequence Models
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
Animal Mitochondrial Genetics
Cis-regulatory Sequences
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Tonicity in Animals
Tonicity in Animals

