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Prevalence of Hypercholesterolemia, High LDL, and Low HDL in Iran: A Systematic Review and Meta-Analysis

Mehdi Akbartabar Toori1, Faezeh Kiani2, Fatemeh Sayehmiri3

  • 1Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Iranian Journal of Medical Sciences
|September 15, 2018
PubMed

Insights

Dyslipidemia, characterized by abnormal lipid levels, is prevalent in Iran, posing significant cardiovascular disease risks. This meta-analysis highlights the substantial burden of high cholesterol, LDL, and low HDL, particularly in women, emphasizing the need for better disease management.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Dyslipidemia, including elevated total cholesterol, LDL cholesterol, and reduced HDL cholesterol, is a major risk factor for cardiovascular diseases.
  • Abnormal lipid profiles contribute to vessel constriction and abstraction, particularly affecting the heart.
  • Understanding the prevalence of dyslipidemia is crucial for public health strategies in Iran.

Purpose of the Study:

  • To estimate the prevalence of various types of dyslipidemia in Iran using a meta-analysis approach.
  • To identify the scope of lipid profile abnormalities within the Iranian population.
  • To provide data for targeted interventions to mitigate cardiovascular disease risks.

Main Methods:

  • A comprehensive literature search was conducted across Persian and English databases (1998-2015).
  • Keywords included 'lipid', 'dyslipidemia', 'CVD', 'cardiovascular risk factors', 'hypercholesterolemia', 'high LDL-C', 'low HDL-C', and 'prevalence'.
  • A random-effects model was employed for data analysis using STATA software.

Main Results:

  • The pooled prevalence for high cholesterol (≥200 mg/dl) was 42% and for high LDL-C (≥130 mg/dl) was 40%.
  • The prevalence of low HDL-C (<40 mg/dl in males, <50 mg/dl in females) was 43%.
  • All forms of dyslipidemia were found to be more prevalent in women compared to men.

Conclusions:

  • The prevalence of dyslipidemia in Iran is substantial, indicating a significant public health concern.
  • Addressing dyslipidemia is critical to reduce the burden of cardiovascular diseases and their complications in Iran.
  • Targeted interventions and improved management strategies are necessary for Iranian populations.
Abstract

Keywords:
DyslipidemiasIranCardiovascular diseases

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