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The total alkaloids from

Jia-Chuan Li1,2, Xiao-Fei Shen3, Jun-Ao Shao2

  • 1Department of Pathophysiology, West China College of Basic and Forensic Medicine, Sichuan University, Chengdu, China, huangpanxiao@sina.com; azure521@gmail.com.

Drug Design, Development and Therapy
|September 15, 2018
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Summary

Total alkaloids from Coptis chinensis (TAC) reversed cognitive deficits in type 2 diabetic rats by improving metabolism, reducing amyloid-beta plaques, and enhancing brain insulin signaling.

Keywords:
Coptis chinensis Franchcognitive deficitsinsulin signalingtotal alkaloidstype 2 diabetes

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Metabolic Disorders

Background:

  • Coptis chinensis Franch is a traditional Chinese medicine used for diabetes and dementia.
  • Alkaloids are the primary active compounds in C. chinensis.

Purpose of the Study:

  • To investigate the effects of total alkaloids from C. chinensis (TAC) on cognitive deficits in type 2 diabetic rats.
  • To elucidate the underlying mechanisms of TAC's action on diabetic cognitive impairment.

Main Methods:

  • Type 2 diabetes and cognitive deficits were induced in rats using streptozotocin and a high glucose/high fat diet.
  • Rats were treated with TAC (80, 120, 180 mg/kg) for 24 weeks, followed by behavioral tests (Morris water maze, Y-maze).
  • Evaluations included glucose/lipid metabolism, brain pathology (Aβ deposition, neuronal damage), and insulin signaling protein phosphorylation (IRS, PI3K, Akt, GSK3β).

Main Results:

  • TAC treatment dose-dependently normalized elevated blood glucose, HbA1c, lipid profiles, and ApoB, while increasing ApoA1.
  • Behavioral tests showed TAC significantly alleviated cognitive deficits in diabetic rats.
  • TAC reversed Aβ deposition and neuronal damage in the brain, and enhanced insulin signaling by increasing IRS, PI3K, and Akt phosphorylation while inhibiting GSK3β.

Conclusions:

  • Total alkaloids from C. chinensis (TAC) demonstrate potential in preventing and treating diabetic cognitive deficits.
  • TAC's therapeutic effects are attributed to improved glucose/lipid metabolism, reduced Aβ burden, and enhanced brain insulin signaling pathways.