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Maria Parvaneh1,2, Golgis Karimi1,3, Rosita Jamaluddin1

  • 1Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia, rositaj@upm.edu.my.

Clinical Interventions in Aging
|September 15, 2018
PubMed
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This summary is machine-generated.

Lactobacillus helveticus supplementation improved bone health in ovariectomized rats. This probiotic enhanced bone formation and reduced resorption, suggesting a therapeutic potential for postmenopausal osteoporosis.

Area of Science:

  • Microbiology
  • Bone Biology
  • Nutritional Science

Background:

  • Osteoporosis is a significant health issue in the elderly, particularly postmenopausal women, leading to fractures and mortality.
  • Bone density loss and hip fractures are common in aging populations, impacting morbidity and mortality rates.

Purpose of the Study:

  • To investigate the effects of Lactobacillus helveticus (L. helveticus) on bone health in ovariectomized (OVX) rats, an established model for postmenopausal osteoporosis.

Main Methods:

  • Rats underwent ovariectomy (OVX) or sham surgery and were divided into three groups: sham, OVX, and OVX treated with L. helveticus.
  • Supplementation with L. helveticus (1 mL of 10^8-10^9 CFU) was administered daily for 16 weeks via force-feeding.

Main Results:

Keywords:
Lactobacillus helveticusbone lossbone mineral densityosteoporosisovariectomized rats

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  • L. helveticus increased bone formation markers (Runx2, Bmp2, osteocalcin) and improved bone structural parameters (bone volume, trabecular thickness).
  • The probiotic decreased bone resorption markers (C-terminal telopeptide) and reduced porosity, leading to enhanced bone mineral density and strength.

Conclusions:

  • L. helveticus attenuates bone remodeling by balancing bone formation and resorption, thereby improving bone health in OVX rats.
  • Lactobacillus helveticus (ATCC 27558) shows promise as a potential therapeutic agent for managing postmenopausal osteoporosis.