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Zhanwang Xiang1,2,3, Lifei Wang4, Huzheng Yan5

  • 1Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Oncotargets and Therapy
|September 15, 2018
PubMed
Summary

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This summary is machine-generated.

125I seed brachytherapy offers better pain relief and quality of life for lung cancer patients with bone metastases compared to external beam radiation therapy (EBRT). This method is also more cost-effective and requires fewer appointments.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Palliative Care

Background:

  • Painful bone metastases are a common complication of lung cancer.
  • External beam radiation therapy (EBRT) is a standard treatment for palliation.
  • The efficacy and cost-effectiveness of alternative treatments require investigation.

Purpose of the Study:

  • To compare the outcomes of 125I seed brachytherapy and EBRT for painful bone metastases in lung cancer patients post-chemotherapy progression.
  • To evaluate pain intensity, quality of life, cost-effectiveness, and treatment appointments.

Main Methods:

  • Retrospective analysis of 158 lung cancer patients with bone metastases.
  • Group A: 76 patients received 125I brachytherapy (96 lesions).
  • Group B: 82 patients received EBRT (98 lesions). Pain and quality of life assessed over 24 weeks.
Keywords:
125I seedEBRTbone metastasesbrachytherapychemotherapylung cancerpain

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Main Results:

  • 125I brachytherapy group showed significantly lower worst pain scores at multiple time points.
  • Superior quality of life scores, cost-effectiveness, and fewer treatment appointments in the 125I brachytherapy group.
  • No significant difference in complication rates between the two groups.

Conclusions:

  • 125I seed brachytherapy is a viable alternative to EBRT for palliation of painful bone metastases in lung cancer patients.
  • This approach offers improved pain control, quality of life, and resource utilization.
  • Further research may support wider adoption of 125I brachytherapy in this patient population.