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Profile of abemaciclib and its potential in the treatment of breast cancer

James M Martin1, Lori J Goldstein2

  • 1Department of Medicine, Section of Hematology/Oncology, Temple University Hospital, Philadelphia, PA, USA, james.martin2@tuhs.temple.edu.

Oncotargets and Therapy
|September 15, 2018
PubMed

Insights

Abemaciclib is a targeted therapy for hormone-receptor-positive breast cancer. This review details its unique properties and role in treating breast cancer patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Hormone-receptor-positive breast cancer is the most common subtype.
  • Targeted inhibitors for cyclin-dependent kinases 4 and 6 (CDK4/6) represent a significant advancement.

Purpose of the Study:

  • To review the current understanding of abemaciclib.
  • To discuss the current and future roles of abemaciclib in breast cancer treatment.

Main Methods:

  • Literature review of abemaciclib's pharmacologic properties and clinical data.
  • Analysis of abemaciclib's unique toxicities and therapeutic applications.

Main Results:

  • Abemaciclib is the most recently approved CDK4/6 inhibitor.
  • It possesses unique pharmacologic properties and potential toxicities.
  • Oral administration and tolerable toxicities make CDK4/6 inhibitors appealing.

Conclusions:

  • Abemaciclib offers a new targeted treatment option for breast cancer.
  • Further research will define its optimal role in various treatment settings.
  • Understanding its unique profile is crucial for effective clinical use.
Keywords:
CDK4/6abemaciclibbreast cancercyclin D1

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