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A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
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A

Mushi Ye1, Zhuobin He2, Wei Dai3

  • 1Department of Urological Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.

Oncology Letters
|September 15, 2018
PubMed

Insights

This study reveals the DNA topoisomerase IIα (TOP2A) gene and its co-expressed genes promote papillary renal cell carcinoma (PRCC) progression. This TOP2A-cancer panel aids in predicting PRCC prognosis and may offer new treatment strategies.

Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • Papillary renal cell carcinoma (PRCC) is a significant subtype of kidney cancer.
  • Understanding the genetic drivers of PRCC progression is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the role of DNA topoisomerase IIα (TOP2A) and its associated genes in PRCC.
  • To identify a gene panel that predicts PRCC prognosis and treatment outcomes.

Main Methods:

  • Utilized online cancer databases (cBioportal, Oncomine, OncoLnc, STRING).
  • Analyzed TOP2A gene expression, function, and regulatory networks in PRCC.
  • Identified co-expressed and mutually exclusive genes with TOP2A.
  • Constructed a protein-protein interaction network for TOP2A-associated genes.

Main Results:

  • A 'TOP2A-cancer panel' of co-expressed genes was identified, promoting PRCC progression.
  • This panel demonstrated strong performance in predicting PRCC prognosis.
  • The TOP2A-cancer panel showed significant differences in affecting PRCC outcomes compared to clear cell renal cell carcinoma (CCRCC).

Conclusions:

  • The TOP2A-cancer panel plays a cooperative role in PRCC progression.
  • This gene panel offers a novel approach for PRCC prognosis prediction.
  • Understanding the TOP2A-cancer panel may lead to new therapeutic interventions for PRCC.
Keywords:
DNA topoisomerase IIαcancer panelpapillary renal cell carcinoma

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