Related Experiment Video
Updated: Feb 5, 2026
06:09
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
Published on: August 20, 2019
16.9K
Morphology regulation in vascular endothelial cells
Kiyomi Tsuji-Tamura1,2, Minetaro Ogawa1
11Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811 Japan.
Inflammation and Regeneration
|September 15, 2018
Summary
Endothelial cell shape changes are vital for forming new blood vessels. This review explores the key genes and signals controlling endothelial cell behavior during vascular development.
Area of Science:
- Cell Biology
- Developmental Biology
- Vascular Biology
Background:
- Endothelial cell (EC) morphology is critical for vascular network formation.
- EC elongation and assembly into vessels precede tube formation.
- Genetic and signaling mechanisms of EC morphology are under investigation.
Purpose of the Study:
- To review transcription factors regulating EC morphology.
- To summarize signaling pathways involved in EC behavior during vascular development.
Main Methods:
- Literature review of in vivo and in vitro studies.
- Focus on genetic and signaling mechanisms.
Main Results:
- Identified key transcription factors influencing EC morphology.
- Detailed signaling pathways regulating EC behavior.
Conclusions:
- Transcription factors and signaling pathways are crucial for EC morphology.
- Understanding these mechanisms is key to vascular development.
Related Concept Videos
01:28pH Regulation in Cells
7.7K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.7K
03:24Seedless Vascular Plants
67.0K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.0K
01:46Epigenetic Regulation
33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
02:58Regulated Protein Degradation
8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
02:14GTPases and their Regulation
9.9K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
9.9K
02:23Master Transcription Regulators
7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K