Effects of chronic treatment with benzodiazepine receptor ligands on cortical adrenoceptors
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Updated: Sep 19, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Abstract:
We report the effects of kindling with the benzodiazepine partial inverse agonist, FG 7142 on adrenoceptor binding in mouse cerebral cortex. Twelve once-daily injections of FG 7142 caused a statistically significant increase in the density of both alpha 2- and beta-adrenoceptor binding sites, seven days after the last injection. Despite the marked effects of FG 7142 on adrenoceptors, there were no changes in either alpha 2- or beta-adrenoceptor binding after prolonged treatment with the benzodiazepine, flurazepam.
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