Modified motor unit number index (MUNIX) algorithm for assessing excitability of alpha motor neuron in spasticity

The understanding of the spasticity mechanism is still a problem in the literature, as its definition can be made on the basis of more than one parameter. Therefore, we studied alpha motor neuron excitability, dynamic changes based on force production, and patellar tendon (T) reflex in spasticity and healthy control groups.

Alpha motor neuron excitability, force production, and patellar T reflex were evaluated through three different test protocols. Motor Unit Number Index (MUNIX) measurement was applied for understanding motor neuron pool properties in the first protocol. Voluntary force production and patellar T reflex parameters were evaluated by voluntary force production and triggering patellar T reflex. Twenty spasticity and 20 healthy volunteers participated in the study.

In the spasticity group, both MUNIX numbers and Motor Unit Size Index (MUSIX) numbers were lower than those in the control group. The results for the Ideal Case Motor Unit Count (ICMUC) parameter show that there is no significant difference between spasticity and healthy individuals for low-level contractions, whereas there is a significant difference for high-level contractions (p < 0.05). In the spasticity group, an increase was observed in the ratio of maximal voluntary force to the T reflex triggered force production (Tf/Vf).

Spasticity and healthy subjects can be distinguished easily and clearly by evaluating the changes in both kinesiological and electrophysiological findings and the decreasing threshold in the alpha motor neuron pool.

This study shows that such combined methods, which allow the evaluation of the alpha motor neuron pool, as well as kinesiological and electrophysiological parameters, are tools that cannot be overlooked in understanding spasticity.