Mapping of atrial fibrillation: strategies to understand an enigmatic arrhythmia

The three-dimensional (3D) mapping of cardiac arrhythmias has evolved in recent years to an important and extremely useful tool, providing important insights into arrhythmia mechanisms and thus improving ablation success rates, especially in complex arrhythmias. In atrial fibrillation (AF), the most common but also one of the most complex cardiac arrhythmias, progress in mapping technology has been focusing on several aspects according to the type of AF.In paroxysmal AF, important progress in the exact anatomic reconstruction of the main ablation target, i.e., the pulmonary veins (PV), has been achieved. Perhaps even more importantly, new insights into conduction patterns, such as deceleration at the PV ostia, spiral conduction more distally into the PV, and PV cross-talk have been detected and enable faster and more sustainable PV isolation.In persistent AF, the basic understanding of ongoing AF is perhaps the electrophysiological challenge of the 21st century. Since AF is instable in its course, mapping tools that assess statistically returning patterns or deal with so-called AF "rotors" or "drivers" have been developed, offering unique insights into possible AF mechanisms. Refined high-density bi-atrial voltage maps make it possible to further characterize the arrhythmogenic substrate and scar zones, while new and innovative mapping algorithms enable automated, fast, and reliable annotation of up to thousands of electrograms.This improved understanding of AF mechanisms has led to the development of promising new ablation strategies, some of which are already in use in clinical routine.