Related Experiment Video
Updated: Feb 5, 2026

An Ex Vivo Laser-induced Spinal Cord Injury Model to Assess Mechanisms of Axonal Degeneration in Real-time
Published on: November 25, 2014
Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury
Courtney M Dumont1, Mary K Munsell1, Mitchell A Carlson1
11 Department of Biomedical Engineering, University of Michigan , Ann Arbor, Michigan.
Impact Statement:
Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor survival after transplantation. Biomaterials can create a cell delivery platform and generate a more hospitable microenvironment for the progenitors within the injury. In this work, polymeric bridges are used to deliver embryonic spinal progenitors to the injury, resulting in increased progenitor survival and subsequent regeneration and functional recovery, thus demonstrating the importance of combined therapeutic approaches for SCI.
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