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Updated: Feb 5, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Roles of microRNAs during glioma tumorigenesis and progression
Shuwei Wang1, Yutong Yin2, Shuang Liu3
1Department of Neurosurgery, Navy General Hospital, PLA, Beijing, China.
Abstract:
Glioma is the most common and aggressive type of brain tumor. It has a poor prognosis and a high recurrence rate. Despite continued advances in surgery, chemotherapy and radiotherapy, the clinical outcomes remain dismal. MicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors. Until now, the molecular mechanism that is responsible for glioma tumorigenesis and progression remains unclear. Increasing evidence has shown that miRNAs play an important role in glioma. In this review, we focus on the current advances in determining the role of miRNAs in regulating tumorigenesis and the progression of glioma. In addition, the relevant roles of miRNAs about the diagnosis and target therapy have been clarified.
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