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Triple extramammary Paget's disease. Immunohistochemical studies
Dermatologica
|January 1, 1986
Summary
This study reports an extremely rare case of Paget's disease affecting three distinct areas: the pubic region and both axillae. Histological and immunohistochemical analyses confirmed the lesions were identical, highlighting a unique presentation of this condition.
Area of Science:
- Dermatology
- Oncology
Background:
- Paget's disease is a rare intraepithelial adenocarcinoma.
- It commonly affects the nipple and vulva, but can occur in other skin sites.
Observation:
- A 75-year-old male presented with three distinct lesions of Paget's disease.
- Lesions were located in the pubic area and bilateral axillae.
- Histological examination revealed no dermal invasion in any lesion.
Findings:
- Histochemical and immunohistochemical studies, including carcinoembryonic antigen (CEA) staining, were performed.
- Genital and axillary lesions demonstrated identical characteristics.
- This triple-site involvement is exceptionally rare in documented cases.
Implications:
- This case expands the understanding of Paget's disease presentation.
- It underscores the importance of thorough examination in suspected cases.
- Further research may elucidate potential underlying mechanisms for multifocal Paget's disease.