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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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951

Association between coronary artery disease and hepatitis C virus seropositivity

Osama Shoeib1, Medhat Ashmawy1, Seham Badr1

  • 1Cardiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = Al-Majallah Al-Sihhiyah Li-Sharq Al-Mutawassit
|September 15, 2018
PubMed

Insights

Hepatitis C virus (HCV) infection may be linked to more severe coronary artery disease (CAD). While not statistically significant, HCV-positive patients showed more multi-vessel disease, suggesting a potential role in CAD progression.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Infectious agents, such as hepatitis C virus (HCV), can act as systemic predisposing factors for CAD.
  • Understanding these associations is crucial for comprehensive cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the potential association between hepatitis C viral infection and the presence and severity of coronary artery disease.
  • To explore if HCV infection influences the extent of coronary artery disease in affected individuals.

Main Methods:

  • A case-control study involving 100 patients undergoing diagnostic angiography.
  • 50 patients with abnormal angiographic findings (cases) were matched with 50 patients with normal findings (controls) based on age, sex, and major CAD risk factors.
  • Hepatitis C virus (HCV) infection status was assessed in all participants.

Main Results:

  • HCV positivity was observed in 46% of patients with abnormal angiography versus 28% in those with normal angiography, a difference lacking statistical significance.
  • Patients with abnormal angiography and HCV infection were more likely to have multi-vessel disease (47.8%) compared to HCV-negative patients (22.2%).
  • Conversely, single-vessel disease was more prevalent in HCV-negative patients (59.3%) than in HCV-positive patients (17.4%).

Conclusions:

  • A potential association exists between hepatitis C virus positivity and the extent of coronary artery disease.
  • HCV may play a role in the pathology of coronary artery disease.
  • Large-scale studies are recommended to further elucidate this association and its clinical implications.
Abstract

Keywords:
atherosclerosiscoronary diseasehepatitis Cstenosis

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