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Published on: October 24, 2019
Associations between red reflex abnormality, consanguinity and intensive care hospitalization of newborns in Turkey
Zeynep Ozkurt1, Selahattin Balsak2, Yusuf Yildirim1
1Department of Ophthalmology, Dicle University of Medicine, Diyarbakir, Turkey.
Insights
Red reflex screening in Southeast Turkey identified significant ocular abnormalities, particularly in newborns with consanguinity. Early detection through this vital eye test is crucial for preventing vision loss.
Area of Science:
- Ophthalmology
- Genetics
- Neonatal Care
Background:
- Red reflex screening is a critical, yet often overlooked, method for identifying serious infant eye conditions.
- Early detection of ocular diseases can prevent vision impairment and address life-threatening issues.
Purpose of the Study:
- To assess newborn red reflex abnormalities in Southeast Turkey.
- To determine the prevalence of ocular diseases linked to abnormal red reflexes.
- To investigate the association between consanguinity and red reflex abnormalities.
Main Methods:
- Examined 1358 newborns using pencil light and direct ophthalmoscopy.
- Categorized newborns into rooming-in units (RIU) and neonatal intensive care services (NICS).
- Analyzed the correlation between consanguineous marriage and abnormal red reflexes.
Main Results:
- Abnormal red reflexes were detected in 0.88% of RIU newborns and 2.51% of NICS newborns.
- The sensitivity of pencil light examination for detecting abnormalities was 71.4%.
- A significant association was found between consanguineous marriage and abnormal red reflexes (P = 0.017).
Conclusions:
- Red reflex screening is essential for the early diagnosis of potentially blinding and life-threatening eye disorders in newborns.
- The high prevalence of consanguinity in Southeast Turkey underscores the importance of this screening in the region.
- Routine screening can facilitate timely intervention for pediatric eye conditions.
Background:
Red reflex screening is the primary but unheeded test for the detection of vision- and life-threatening eye conditions.
Aims:
To evaluate the red reflex of newborns, percentage of ocular diseases resulting in red reflex abnormality, and their relation with consanguinity in Southeast Turkey.
Methods:
Newborns (n = 1358) were examined with pencil light and direct ophthalmoscopy.
Results:
Eight hundred of these newborns were hospitalized in a rooming-in unit. (RIU) and 558 were in the neonatal intensive care service (NICS). In the RIU there were 7 (0.88%) newborns with abnormal red reflex and in the NICS there were 14 (2.51%). Sensitivity of pencil light examination was 71.4%. Studies from the Middle East have shown potential recessive genetic causes of common paediatric ocular conditions. In our study, consanguineous marriage was found to have a significant association with red reflex abnormality (P = 0.017).
Conclusions:
Red reflex screening test is important in the early diagnosis of vision- and life-threatening eye disorders in Southeast Turkey where consanguinity is common.
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