Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Copper and hepatocellular carcinoma.

F M Vecchio, F Federico, M A Dina

    Digestion
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Fibrolamellar carcinoma (FLC) shows significant copper and copper-binding protein (CBP) storage in tumor cells, unlike most hepatocellular carcinoma (HCC) with cirrhosis. This copper accumulation is linked to the oncocytic appearance of FLC cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PATTERN OF A PRIMARY B-CELL LYMPHOMA IN ULNAR NERVE: INTRANEURAL OR EXTRANEURAL.

    Georgian medical news·2023
    Same author

    The role of postoperative radiotherapy in eccrine porocarcinoma: a multidisciplinary systematic review.

    European review for medical and pharmacological sciences·2022
    Same author

    Recurrent hepatocellular carcinoma and non-classic adreno-genital syndrome.

    European review for medical and pharmacological sciences·2020
    Same author

    Skin cancer triage and management during COVID-19 pandemic.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2020
    Same author

    Is hyaluronidase able to reverse embolism associated with hyaluronic acid filler? An anatomical case study.

    Journal of biological regulators and homeostatic agents·2020
    Same author

    Critical analysis of major and ancillary features of LI-RADS v2018 in the differentiation of small (≤ 2 cm) hepatocellular carcinoma from dysplastic nodules with gadobenate dimeglumine-enhanced magnetic resonance imaging.

    European review for medical and pharmacological sciences·2019

    Area of Science:

    • Hepatobiliary pathology
    • Oncology
    • Trace element research

    Background:

    • Hepatocellular carcinoma (HCC) associated with cirrhosis (HCC + C) is a common malignancy.
    • Fibrolamellar carcinoma (FLC) is a rare subtype of HCC, typically occurring in younger individuals without cirrhosis.
    • The role of copper and copper-binding protein (CBP) in liver cancer pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the presence and distribution of copper and CBP in tumor cells of HCC + C and FLC.
    • To determine if copper accumulation is a characteristic feature of FLC.
    • To explore the relationship between copper storage and the morphological features of tumor cells.

    Main Methods:

    • Histochemical staining (rhodanine, rubeanic acid, Shikata's orcein) was used to detect copper and CBP.

    Related Experiment Videos

  • The study analyzed 39 autopsy cases of HCC + C and 2 surgical cases of FLC.
  • Ultrastructural examination was performed on copper-positive tumor cells.

    • Main Results:

    • Considerable copper and CBP were found within tumor cells exclusively in the 2 FLC cases and in one HCC + C case with FLC-like areas.
    • Copper-positive tumor cells exhibited an oncocytic appearance.
    • In 64% of HCC + C cases, copper and CBP deposits were observed in nonneoplastic hepatocytes around cirrhotic nodules.

    Conclusions:

    • Intratumoral copper storage is a distinctive feature of fibrolamellar carcinoma (FLC), correlating with its oncocytic cellular morphology.
    • The findings suggest a potential link between copper accumulation and the specific characteristics of FLC.
    • The role of copper deposits in nonneoplastic cirrhotic hepatocytes requires further investigation.