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Total synthesis of sesterterpenoids.
Yuye Chen1, Jing Zhao, Shaoping Li
1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China. jingzhao@umac.mo zhaojing.cpu@163.com.
Natural Product Reports
|September 15, 2018
Summary
This review covers total syntheses of sesterterpenoids from 2012-2018. It highlights key transformations for these complex terpenes with unique biological activities.
Area of Science:
- Organic Chemistry
- Natural Product Synthesis
Background:
- Sesterterpenoids are a class of terpenes known for complex structures.
- These compounds often exhibit significant biological activities.
Purpose of the Study:
- To review and discuss the total syntheses of sesterterpenoids.
- To cover literature published between January 2012 and January 2018.
- To highlight key chemical transformations in these syntheses.
Main Methods:
- Literature review of total sesterterpenoid syntheses.
- Analysis of synthetic strategies and methodologies.
- Identification of crucial chemical transformations.
Main Results:
- A summary of published total syntheses of sesterterpenoids.
- Highlighting of innovative synthetic approaches.
- Discussion of challenging chemical steps involved.
Conclusions:
- The field of sesterterpenoid total synthesis has seen significant advancements.
- Methodological and strategic innovations are crucial for tackling these complex molecules.
- This review provides a valuable resource for synthetic chemists.
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