Related Experiment Video

Updated: Feb 5, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
06:25

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Published on: December 23, 2016

9.6K

Distinct Biological Phenotypes of Marburg and Ravn Virus Infection in Macaques

Veronica V Nicholas1, Rebecca Rosenke2, Friederike Feldmann2

  • 1Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.

The Journal of Infectious Diseases
|September 15, 2018
PubMed

Insights

This study compares Ravn virus (RAVV) and Marburg virus (MARV) strains in nonhuman primates. Results show varying pathogenicity, with implications for understanding filovirus virulence and endothelial cell infection.

Area of Science:

  • Virology
  • Pathogen research

Background:

  • Filoviruses, including Marburg virus (MARV), are highly pathogenic human infectious agents.
  • MARV has caused devastating outbreaks, necessitating further research into its virulence.

Purpose of the Study:

  • To compare the pathogenesis of Ravn virus (RAVV) and three MARV strains (Angola, Musoke, Ozolin).
  • To evaluate pathogenicity in rhesus and cynomolgus macaques, key models for filovirus research.

Main Methods:

  • Comparative analysis of RAVV and MARV strains in nonhuman primate models.
  • Assessment of pathogenicity and tissue tropism.

Main Results:

  • MARV Angola was most pathogenic, followed by Musoke; Ozolin was least pathogenic.
  • RAVV exhibited high pathogenicity in cynomolgus macaques but lower in rhesus macaques.
  • MARVs preferentially infect endothelial cells, and lymphocyte/hepatocyte apoptosis may contribute to pathogenicity.

Conclusions:

  • Pathogenicity of MARV strains and RAVV varies significantly between macaque species.
  • Endothelial cell infection and apoptosis are key factors in MARV pathogenesis.

More Related Videos

Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination15:25

Protocol for Dengue Infections in Mosquitoes A. aegypti and Infection Phenotype Determination

Published on: July 4, 2007

19.1K
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

10.4K

Related Concept Videos

What are Viruses?00:50

What are Viruses?

Overview
128.2K
What is Conservation Biology?01:57

What is Conservation Biology?

Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.4K
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
626
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.7K