Cancer is not a risk factor for bullous pemphigoid: 10-year population-based cohort study
C T Chen1,2, H Y Hu3,4, Y T Chang1,2
1Department of Dermatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
The British Journal of Dermatology
|September 15, 2018
Summary
This study found that cancer patients do not have a higher risk of developing bullous pemphigoid (BP). Cancer is not a risk factor for BP, according to this large-scale population study.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Bullous pemphigoid (BP) is the most common autoimmune blistering disease.
- The relationship between cancer and the risk of developing BP remains unclear.
Purpose of the Study:
- To investigate the risk of subsequent bullous pemphigoid in patients diagnosed with cancer.
Main Methods:
- A nationwide population-based cohort study utilized data from the Taiwan National Health Insurance Database (2000-2011).
- Included 36,838 cancer patients and 147,352 matched controls.
- Analyzed the hazard ratio (HR) of subsequent BP using a Fine-Gray competing risk regression model.
Main Results:
- The incidence of BP was 17.2 per 100,000 person-years in cancer patients versus 19.8 in controls (crude incidence rate ratio: 0.87).
- The adjusted HR for subsequent BP in cancer patients was 0.47 (95% CI 0.23-0.94).
- Independent risk factors for BP included older age, diabetes mellitus, and cerebrovascular disease.
Conclusions:
- The incidence of bullous pemphigoid is not elevated in cancer patients compared to the general population.
- Cancer is not identified as a risk factor for developing bullous pemphigoid.
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