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Spontaneous epimutations in plants.

Frank Johannes1,2, Robert J Schmitz2,3

  • 1Department of Plant Sciences, Technical University of Munich, Liesel-Beckmann-Str. 2, Freising, 85354, Germany.

The New Phytologist
|September 15, 2018
PubMed
Summary
This summary is machine-generated.

Spontaneous epimutations, heritable changes in plant DNA methylation without altering DNA sequence, occur due to imperfect epigenome maintenance. These epimutations can impact gene expression and population diversity.

Keywords:
DNA methylationcomplex traitsepigenetic inheritancegenome evolutionplant epigeneticsplant evolution

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Area of Science:

  • Plant epigenetics
  • Molecular biology
  • Genomics

Background:

  • Heritable gains or losses of cytosine methylation (epimutations) occur stochastically in plant genomes.
  • These events are independent of DNA sequence changes and arise from imperfect DNA methylation maintenance.

Purpose of the Study:

  • To synthesize current knowledge on the molecular basis of spontaneous epimutations in plants.
  • To explore the functional consequences of these epimutations.
  • To discuss challenges and future research directions in plant epigenetics.

Main Methods:

  • Literature review and synthesis of existing research on spontaneous epimutations.
  • Analysis of molecular mechanisms underlying epimutation occurrence.
  • Evaluation of phenotypic and population-level impacts.

Main Results:

  • Spontaneous epimutations are a byproduct of epigenome maintenance in specialized plant cells.
  • These epimutations can lead to heritable gene expression changes.
  • They contribute to methylation diversity within and among plant populations and respond to environmental stressors.

Conclusions:

  • Spontaneous epimutations are a significant source of epigenetic variation in plants.
  • Understanding their molecular basis and consequences is crucial for plant epigenetics research.
  • Further investigation is needed to address technical and conceptual challenges.