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Related Concept Videos

Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
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Crystal Field Theory
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Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
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Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method.

Jia Yao1,2, Bin Feng3, Zhiqi Zhang4

  • 1CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China. yaojia@sibet.ac.cn.

Sensors (Basel, Switzerland)
|September 16, 2018
PubMed
Summary
This summary is machine-generated.

A new smartphone-based device uses quartz crystal microbalance (QCM) dissipation to monitor blood coagulation. This portable platform offers reliable self-testing for patients on anticoagulation therapy.

Keywords:
blood coagulationdissipationpoint of care testingquartz crystal microbalancesmartphone

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Monitoring blood coagulation is crucial for patients undergoing anticoagulation therapy.
  • Existing methods often require laboratory settings, necessitating a need for portable self-testing devices.
  • Quartz Crystal Microbalance (QCM) dissipation monitoring offers a sensitive method for detecting changes in biological samples.

Purpose of the Study:

  • To develop and validate a novel smartphone-based platform for blood coagulation self-testing.
  • To utilize QCM dissipation measurement for analyzing blood coagulation parameters.
  • To assess the platform's accuracy in measuring activated partial thromboplastin time (APTT) and prothrombin time (PT).

Main Methods:

  • A smartphone-based platform was developed using a parylene-C coated quartz crystal microbalance (QCM) sensor.
  • The QCM sensor's dissipation factor was measured to analyze fibrin capture and blood coagulation.
  • Data transmission via Bluetooth to a smartphone enabled real-time calculation of coagulation indexes (APTT and PT).

Main Results:

  • The parylene-C coating provided a robust surface for fibrin capturing.
  • High correlation was observed between the QCM platform and a commercial hemostasis system.
  • Adjusted R-square values of 0.985 for APTT and 0.961 for PT demonstrated excellent measurement accuracy.

Conclusions:

  • The QCM dissipation method is a reliable and effective technique for blood coagulation measurement.
  • The developed smartphone-based platform offers a promising solution for point-of-care blood coagulation testing.
  • This technology can empower patients with anticoagulation therapy to perform self-monitoring conveniently and accurately.