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Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications.
Ibrahim El Halabi1, Rachelle Bejjany2, Rihab Nasr3
1Department of Internal Medicine-Division of Hematology-Oncology, American University of Beirut Medical Center, Riad El Solh, Beirut 1107 2020, Lebanon. ije03@mail.aub.edu.
Intravenous ascorbic acid (vitamin C) shows promise for colorectal cancer by disrupting cancer cell metabolism. Further clinical trials are needed to confirm its therapeutic benefits in patients.
Area of Science:
- Oncology
- Biochemistry
- Metabolic pathways
Background:
- Colorectal cancer (CRC) exhibits altered cellular metabolism, specifically the Warburg effect, facilitating increased glucose uptake.
- Intravenous ascorbic acid (AA) administration is being explored for its potential benefits in cancer therapy.
Purpose of the Study:
- To review the potential benefits of intravenous AA in colorectal cancer.
- To focus on the effects of AA on glycolysis in KRAS and BRAF mutant and wild-type colorectal cancer cells.
Main Methods:
- A literature search was conducted using PubMed and Ovid MEDLINE.
- Keywords included: ascorbic acid, intravenous vitamin C, KRAS mutation, BRAF mutation, and colorectal cancer (CRC).
Main Results:
- AA disrupts the Warburg effect in colorectal cancer cells.
- AA can shut down the downstream KRAS pathway in KRAS-mutated colon cancer cells.
- Clinically, AA is linked to tumor regression and improved tolerability of standard cancer therapies.
Conclusions:
- Intravenous ascorbic acid demonstrates potential therapeutic benefits in colorectal cancer.
- Further large-scale clinical trials are warranted to validate the efficacy of AA in colon cancer treatment.
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