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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

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In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Andrea Vaupel1, Philipp Holzer1, Stephane Ferretti1

  • 1Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

Bioorganic & Medicinal Chemistry Letters
|September 16, 2018
PubMed

Keywords:
HDM201MDM2-p53 protein-protein interaction (PPI) inhibitorsPyrrolo[3,4-d]imidazol-4(1H)- onesStructure guided designX-ray structure

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