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First report of bla
Zineb Leulmi1, Chouaib Kandouli2, Ilhem Mihoubi3
1Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, URMITE CNRS-IRD, UMR 6236, Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, Marseille, France; Laboratoire Microbiologie, CHU de Constantine, Constantine, Algeria.
Journal of Global Antimicrobial Resistance
|September 16, 2018
Summary
Carbapenem-resistant Enterobacteriaceae pose a significant threat. This study identified a multidrug-resistant Proteus mirabilis strain in Algeria carrying novel resistance genes, including blaOXA-24.
Area of Science:
- Microbiology
- Genetics
- Infectious Diseases
Background:
- Carbapenemase-producing Enterobacteriaceae (CPE) are a growing global health concern.
- These bacteria exhibit resistance to last-line antibiotics, complicating infection treatment.
- Proteus mirabilis is a common cause of healthcare-associated infections.
Purpose of the Study:
- To analyze antimicrobial resistance patterns and genes in Proteus mirabilis isolates from Constantine, Algeria.
- To identify novel resistance mechanisms in clinical isolates.
Main Methods:
- Isolation and identification of Proteus, Morganella, and Providencia (PMP) strains from clinical specimens.
- Antimicrobial susceptibility testing using disk diffusion and Etest.
- Detection of antimicrobial resistance genes via PCR and sequencing.
Main Results:
- 72 out of 108 PMP strains were multidrug-resistant (MDR).
- One MDR Proteus mirabilis isolate showed resistance to imipenem (MIC ≥12μg/mL).
- This isolate harbored blaOXA-24, armA, and aac(6')-Ib-cr genes, among others.
Conclusions:
- A multidrug-resistant Proteus mirabilis isolate with blaOXA-24, armA, and aac(6')-Ib-cr genes was identified for the first time in Algeria.
- This finding highlights the emergence of carbapenem resistance in P. mirabilis in the region.
- Continuous surveillance for antimicrobial resistance is crucial.
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