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First report of bla

Zineb Leulmi1, Chouaib Kandouli2, Ilhem Mihoubi3

  • 1Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, URMITE CNRS-IRD, UMR 6236, Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, Marseille, France; Laboratoire Microbiologie, CHU de Constantine, Constantine, Algeria.

Journal of Global Antimicrobial Resistance
|September 16, 2018
PubMed
Abstract

Insights

Carbapenem-resistant Enterobacteriaceae pose a significant threat. This study identified a multidrug-resistant Proteus mirabilis strain in Algeria carrying novel resistance genes, including blaOXA-24.

Area of Science:

  • Microbiology
  • Genetics
  • Infectious Diseases

Background:

  • Carbapenemase-producing Enterobacteriaceae (CPE) are a growing global health concern.
  • These bacteria exhibit resistance to last-line antibiotics, complicating infection treatment.
  • Proteus mirabilis is a common cause of healthcare-associated infections.

Purpose of the Study:

  • To analyze antimicrobial resistance patterns and genes in Proteus mirabilis isolates from Constantine, Algeria.
  • To identify novel resistance mechanisms in clinical isolates.

Main Methods:

  • Isolation and identification of Proteus, Morganella, and Providencia (PMP) strains from clinical specimens.
  • Antimicrobial susceptibility testing using disk diffusion and Etest.
  • Detection of antimicrobial resistance genes via PCR and sequencing.

Main Results:

  • 72 out of 108 PMP strains were multidrug-resistant (MDR).
  • One MDR Proteus mirabilis isolate showed resistance to imipenem (MIC ≥12μg/mL).
  • This isolate harbored blaOXA-24, armA, and aac(6')-Ib-cr genes, among others.

Conclusions:

  • A multidrug-resistant Proteus mirabilis isolate with blaOXA-24, armA, and aac(6')-Ib-cr genes was identified for the first time in Algeria.
  • This finding highlights the emergence of carbapenem resistance in P. mirabilis in the region.
  • Continuous surveillance for antimicrobial resistance is crucial.
Keywords:
Multidrug-resistantPMPProteus mirabilisaac(6′)-Ib-crarmA methyltransferasebla(OXA-24)

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