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Updated: Feb 5, 2026

Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response
Published on: November 10, 2023
Immunogenic cell death in anticancer chemotherapy and its impact on clinical studies
Qiang Wang1, Xiaoli Ju2, Jiayou Wang1
1Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, PR China.
Abstract:
The traditional view holds that apoptosis is non-immunogenic and does not induce an inflammatory response. However, recent studies have suggested that certain chemotherapeutic drugs that induce tumor cell apoptosis can induce immunogenic cell death (ICD) in cancer cells. This process is characterized by not only up-regulation of a series of signaling molecules in cancer cells, including expose of calreticulin (CRT), secretion of adenosine triphosphate (ATP) and release of high mobility group box 1 (HMGB1). In this review, we summarize recent progress in identifying and classifying ICD inducers; concepts and molecular mechanisms of ICD; and the impact and potential applications of ICD in clinical studies. We also discuss the contributions of ICD inducers in combination with other anticancer drugs in clinical applications.
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