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Related Concept Videos

Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Gene Families01:57

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Family Therapy01:30

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Family therapy conceptualizes psychological challenges as arising from dysfunctional interactions within the family unit, rather than as isolated issues within individuals. This approach seeks to address and transform the patterns of communication, roles, and relationships within families to promote healthier dynamics and emotional well-being for all members.
Strategic Family Therapy
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In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
Lintels are primary supports used to span openings and can be crafted from materials such as reinforced concrete, steel-reinforced brick masonry, or simple steel angles. These are straightforward to install and are typically concealed...
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Related Experiment Video

Updated: Feb 5, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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[Familial chilblain lupus: Four cases spanning three generations].

A-S Beltoise1, C Audouin-Pajot2, P Lucas1

  • 1Service de dermatologie, hôpital Larrey, CHU de Toulouse, 24, chemin de Pouvourville, 31400 Toulouse, France.

Annales De Dermatologie Et De Venereologie
|September 16, 2018
PubMed
Summary

Familial chilblain lupus is a rare genetic condition causing skin inflammation. This study reports a new family with this lupus erythematosus variant, highlighting the need for further genetic investigation as known gene mutations were not found.

Area of Science:

  • Genetics
  • Immunology
  • Dermatology

Background:

  • Familial chilblain lupus is a rare, hereditary cutaneous lupus erythematosus.
Keywords:
Chilblain lupusInterferon signatureInterféronopathie de type 1Lupus-engelures familialSAMHD1STINGSignature interféronTREX-1Type 1 interferonopathy

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  • It is an autosomal dominant condition linked to mutations in TREX-1, SAMHD1, or TMEM173 (STING) genes.
  • This disease is classified as a type I interferonopathy, characterized by excessive interferon production.